MyBioSource.com's E2F2 Antibody (Center) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The E2F2 Antibody (Center) was generated using E2F2 as the antigen and it reacts with Human, and Mouse.
Description
E2F2 is a member of the E2F
family of transcription factors. The E2F family plays a crucial
role in the control of cell cycle and action of tumor suppressor
proteins and is also a target of the transforming proteins of small
DNA tumor viruses. The E2F proteins contain several evolutionally
conserved domains found in most members of the family. These
domains include a DNA binding domain, a dimerization domain which
determines interaction with the differentiation regulated
transcription factor proteins (DP), a transactivation domain
enriched in acidic amino acids, and a tumor suppressor protein
association domain which is embedded within the transactivation
domain. This protein and another 2 members, E2F1 and E2F3, have an
additional cyclin binding domain. This protein binds specifically
to retinoblastoma protein pRB in a cell-cycle dependent manner, and
it exhibits overall 46% amino acid identity to E2F1. [provided by
RefSeq]